Chenbo Ding, Ph.D.

丁陈波

Position：

Associate Professor (2024)

Postdoctoral Fellow (2021)

Email：

chenbo.ding@sjtu.edu.cn

dcb06296632@163.com

Education:

2016-2020       Southeast University, School of Medicine, Ph.D.

2018-2020       Yale University, School of Medicine, Joint Ph.D

2013-2016       Zunyi Medical University, M.D.

2006-2009       Hubei University of Chinese Medicine, B.S.

Research Interest:

The roles of RNA epigenetics in intestinal epithelial barrier, intestinal mucosal immunity, and enteric nervous system upon inflammation and tumor.

Publication:

1. Ding C#, Yu Z#, Sefik E#, Zhou J#, Kaffe E, Wang G, Li B, Flavell RA, Hu W, Ye Y, Li HB*. (2023) A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver. Nature Aging. 2023 Jul; 3(7):813-828. doi: 10.1038/s43587-023-00428-8. Epub 2023 Jun 5. PMID: 37277640.

2. Ting Zhang#; Chenbo Ding#,*; Huifang Chen#; Jun Zhao; Zhejun Chen; Baiwen Chen; Kaiqiong Mao; Yajuan Hao; Manolis Roulis; Hao Xu; Yuval Kluger; Qiang Zou; Youqiong Ye; Meixiao Zhan*; Richard A. Flavell*; Hua-Bing Li*; m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated anti-apoptotic pathway, Science Advances, 2022, 8(eabl5723).

3. Liwen Yang#; Chenbo Ding#,*; Wendong Tang; Taoyu Yang; Min Liu; Hailu Wu; Kunming Wen; Xinsheng Yao; Jihong Feng*; Junmin Luo*; INPP4B exerts a dual function in the sternness of colorectal cancer stern-like cells through regulating Sox2 and Nanog expression, Carcinogenesis, 2020, 41(1): 78-90.

4. Chenbo Ding*; Wendong Tang; Hailu Wu; Xiaobo Fan; Junmin Luo; Jihong Feng; Kunming Wen; Guoqiu Wu*; The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K/Akt signalling in colorectal cancer, Cancer Letters, 2019, 442: 383-395.

5. Wendong Tang#; Liwen Yang#; Taoyu Yang#; Min Liu; Yanjie Zhou; Jiang Lin; Ke Wang*; Chenbo Ding*; INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma, OncoTargets and Therapy, 2019, 12:3491-3507.

6. Chenbo Ding#,*; Wendong Tang#; Xiaobo Fan; Xiyong Wang; Hailu Wu; Hongbo Xu; Wei Xu; Wei Gao; Guoqiu Wu*; Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling, Cell Death & Disease, 2018, 9(8):802.

7. Chenbo Ding; Wendong Tang; Xiaobo Fan; Guoqiu Wu*; Intestinal microbiota: a novel perspective in colorectal cancer biotherapeutics, OncoTargets and Therapy, 2018, 11:4797-4810.

8. Chenbo Ding; Junmin Luo*; Xiaobo Fan; Longmei Li; Shanshan Li; Kunming Wen; Jihong Feng*; Guoqiu Wu*; Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels, Journal of Experimental & Clinical Cancer Research, 2017, 36(1): 0-56.

9. Chenbo Ding; Xiaobo Fan; Guoqiu Wu*; Peroxiredoxin 1 - an antioxidant enzyme in cancer, Journal of Cellular and Molecular Medicine, 2017, 21(1):193-202.

10. Chenbo Ding; Longmei Li; Taoyu Yang; Xiaobo Fan; Guoqiu Wu*; Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model, BMC Cancer, 2016, 16(1):791.

11. Chenbo Ding#; Junmin Luo#; Longmei Li; Shanshan Li; Liwen Yang; Hongfei Pan; Qianyi Liu; Huan Qin; Chao Chen; Jihong Feng*; Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer, Journal of Experimental & Clinical Cancer Research, 201 6, 35(1): 0-5.