Principal Investigator

Hua-Bing Li, Ph.D.

李华兵 研究员，国家杰青

Position：

Principal Investigator,

Shanghai Institute of Immunology &

Chongqing Medical University

Distinguished Professor Adjunct,

Center for Immunology & Diseases Research, Ruijin Hospital

Assistant Professor Adjunct,

Department of Immunobiology,

Yale Medical School

Office： 86-021-63846590-776794

Email：huabing.li@shsmu.edu.cn

huabing.li@yale.edu

Office Location：Room 602, No.5 Bldg., West Area, 280 South Chongqing Rd., Shanghai.

上海市黄浦区重庆南路280号西5号楼602室

PROFILE @ SHSMU

Biography:

Dr. Li graduated from Nankai University with B.S. and M.S. degrees, then obtained his Ph.D. degree in Biochemistry in 2011 in Vincenzo Pirrotta lab at Rutgers, the state University of New Jersey, working on Polycomb mediated long-distance chromatin interactions in Drosophila. He continued his postdoc training with Dr. Richard Flavell at Yale University School of Medicine since 2012, working on regulatory RNAs and RNA epigenetic switches of the immune system.

Dr. Li established his independent lab at Shanghai Jiao Tong University School of Medicine since 2017. The lab is especially interested in the physiological functions and molecular mechanisms of RNA epigenetic modifications and related RNA binding proteins in immune cells and related immune disease with mouse disease models. Combined with the state-of-the-art technologies and international collaboration, we aim to reveal novel fucntions and mechanisms of inflammation and autoimmune disease, which will contribute to the identification of potential targets for anti-autoimmune and anti-tumor drug development.

 

Education & Experience：

Education

2012 - 2017, Yale University, New Haven, CT, USA, Postdoc
Advisor: Richard A. Flavell

2011 - 2012, Rutgers University/ UMDNJ, Piscataway, NJ, USA, Postdoc

Advisor: Vincenzo Pirrotta

2005 - 2011, Rutgers University/ UMDNJ, Piscataway, NJ, USA, Ph.D.

2002 - 2005, Nankai University, Tianjin, China, M.S.

1999 - 2002, Nankai University, Tianjin, China, B.S.  

Work Experience

2024 - present, Chongqing Medical University, Member of the Standing Committee of the Party Committee, Vice-President and Dean, Institute of Immunology & Disease Research

2022 - present, Center for Immunology & Diseases Research, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Distinguished Professor Adjunct

2018 - present, Yale University School of Medicine, Assistant Professor Adjunct

2017 - present, Shanghai Institute of Immunology, Principal Investigator  

Selected Publication

( *:co-corresponding authors 共同通讯作者; #:co-first authors 共同第一作者)

  1. Li HB, Muller M, Bahechar I, Kyrchanova O, Ohno K, Georgiev P, and Pirrotta V. (2011) Insulators, not Polycomb Response Elements, are required for long-range interactions between Polycomb targets in Drosophila. Mol. Cell. Biol., 31(4):616-25. doi: 10.1128/MCB.00849-10. PMID: 21135119

  2. Li HB, Ohno K, Gui H, and Pirrotta V. (2013) Insulators target active genes to transcription factories and Polycomb-repressed genes to PcG bodies. PLoS Genet., 9(4):e1003436. doi: 10.1371/journal.pgen.1003436. PMID: 23637616 (Highlighted by Cell: 153(5), p935)

  3. Hu B#, Jin C#, Li HB#, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. (2016) The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury. Science, 354 (6313): 765-768. DOI: 10.1126/science.aaf7532. PMID: 27846608 (# equal contribution)

  4. Li HB#*, Tong J#, Zhu S#, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z*, Flavell RA*. (2017) m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway. Nature, 2017 Aug 17;548(7667):338-342. doi: 10.1038/nature23450. Epub 2017 Aug 9. PMID: 28792938 (# equal contribution, * co-corresponding) （ESI highly cited paper）

  5. Tong J#, Cao G#, Zhang T#, Sefik E, Vesely M, Broughton J, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA*, Li HB*. (2018) m6A mRNA methylation sustains Treg suppressive functions. Cell Research, 28(2): 253-256. doi:10.1038/cr.2018.7. PMID: 29303144 (*co-corresponding)

  6. Gao Y*#, Vasic R#, Song Y#, Teng R, Gbyli R, Biancon G, Nelakanti R, Liu C, Kudo E, Lobben K, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA*, Li HB*, Tebaldi T*, Halene S*. (2020) Activation of Double-Stranded RNA Innate Immune Response and Hematopoietic Failure upon Loss of METTL3-Mediated m6A RNA Modification. Immunity, 2020 Jun 16;52(6):1007-1021.e8. doi: 10.1016/j.immuni.2020.05.003. Epub 2020 Jun 3. PMID: 32497523 (* co-corresponding)

  7. Chen H#, Yao J#, Bao R, Dong Y, Zhang T, Du Y, Wang G, Ni D, Xun Z, Niu X, Ye Y*, Li HB*. (2021) Cross-talk of Four Types of RNA Modification Writers Defines Tumor Microenvironment and Pharmacogenomic Landscape in Colorectal Cancer. Molecular Cancer, 20(1):29. doi: 10.1186/s12943-021-01322-w. PMID: 33557837 (* co-corresponding) （ESI highly cited paper）

  8. Tong J#, Wang X#, Liu Y#, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, Zou Q, Zhou Y, Xia Q*, Flavell RA*, Zhu S*, Li HB*. (2021) Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation. Science Advances, 2021 Apr 28; 7(18):eabd4742. doi: 10.1126/sciadv.abd4742. PMID: 33910903 (* co-corresponding)

  9. Zhou J#, Zhang X#, Hu J#, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, Wang Z, Flavell RA*, Li HB*. (2021) m6A Demethylase ALKBH5 Controls CD4+ T cell Pathogenicity and Promotes Autoimmunity. Science Advances, 2021 Jun 16; 7(25):eabg0470. doi: 10.1126/sciadv.abg0470. PMID: 34134995 (* co-corresponding)

  10. Zhang T#, Ding C#*, Chen H# Zhao J, Chen J, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M*, Flavell RA*, Li HB*. (2022) m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κb-mediated anti-apoptotic pathway. Science Advances, 2022 Mar 25; 8(12):eabl5723. doi: 10.1126/sciadv.abl5723. PMID: 35333576

  11. Chen B#, Hu J#, Hu X#, Chen H, Bao R, Zhou Y, Ye Y, Zhan M*, Cai W*, Li H*, Li HB*. (2022) DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nature Communications, 2022 Apr 19; 13(1):2059. doi: 10.1038/s41467-022-29754-y. PMID: 35440133

  12. Ding C#, Xu H#, Yu Z#, Roulis M, Qu R, Zhou J, Oh J, Craford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W*, Flavell RA*, Li HB*. (2022) RNA m6A demethylase ALKBH5 regulates the development of γδ T cells. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2203318119. doi: 10.1073/pnas.2203318119. Epub 2022 Aug 8. PMID: 35939687

  13. Liu Y#, Zhou J#, Li X#, Zhang X#, Shi J#, Wang X, Li H, Miao S, Chen H, He X, Dong L, Lee GR, Zhen J, Liu RJ, Su B, Ye Y, Flavell RA*, Yi C*, Wu Y*, Li HB*. (2022) tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis. Nature Immunology, 2022 Oct; 23(10):1433-1444. doi: 10.1038/s41590-022-01301-3. Epub 2022 Sep 22. PMID: 36138184. (Cover Article. Highlighted by: News & Views: Marchingo, J.M. Nat Immunol 23, 1401–1402 (2022). Research Briefing: Nat Immunol 23, 1408–1409 (2022). Research Highlight: Pei W. & Kuchroo V.K. Cell Res. 33(4):271-272. Research Highlight: Chen C. & Ye L. Cell Mol Immunol., 19(12):1328-1329. Research Highlight: Lin P., Li G. & Wu M. Signal Transduct Target Ther. 8(1):78.)

  14. Ding C#, Yu Z#, Sefik E#, Zhou J#, Kaffe E, Li B, Wang L, Flavell RA, Hu W, Ye Y, Li HB*. (2023) A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver. Nature Aging, 2023 Jul; 3(7):813-828. doi: 10.1038/s43587-023-00428-8. Epub 2023 Jun 5. PMID: 37277640. (Highlighted by: News & Views: Ma Y. & Cao H. Nature Aging, 3, 760–761 (2023); Research Highlight: Hguyen H.T. & Batista P.J. Sci China Life Sci. 66)

  15. Chen Y, Chen B, Li J, Li H, Wang G, Cai X, Zhang Q, Liu X, Kan C, Wang L, Wang Z, Li HB*. (2024) Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway. Cell Mol Immunol. 2024 Dec;21(12):1522-1534. doi: 10.1038/s41423-024-01237-8. Epub 2024 Nov 13.

  16. Miao S, Li H, Song X, Liu Y, Wang G, Kan C, Ye Y*, Liu R*, Li HB*. (2025) tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells. J Exp Med. 2025 Mar 3;222(3):e20240559. doi: 10.1084/jem.20240559. Epub 2025 Jan 28. PMID: 39873720