Xin Wang, Ph.D.

王鑫

Position:

Associate Professor

Email:

xin.wang@cqmu.edu.cn

Education:

University of Göttingen (Göttingen, Germany) 2016.10 – 2020.10

PhD program: International Max-Planck Research School - Genome Science

Supervisor: Prof. Steven A. Johnsen

Northwest A&F University (Yangling, China) 2014.09 – 2016.06

M. Sc. (College of Horticulture)

Supervisor: Prof. Sanwen Huang & Prof. Xiaofeng Wang

Northwest A&F University (Yangling, China) 2010.09 – 2014.07

B. Sc. (Innovative Experimental College)

Work Experiences:

2025.07 – present, Associate Professor, School of Basic Medical Sciences, Chongqing Medical University (Chongqing,China)

2024.07 – 2025.05, Assistant Research Fellow, Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (Shenzhen, China)

2022.04 – 2024.06, Post-Doctoral Fellow, Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (Shenzhen, China)

2021.06 – 2022.03, Associate Research Fellow, Guangdong Provincial People’s Hospital (Guangzhou, China)

2020.10 – 2021.03, Post-Doctoral Fellow, University Medical Center Göttingen (Göttingen, Germany)

Research Interests:

Epigenetic regulation and evolutionary dynamics of drug resistance.

Epigenetic and metabolic regulatory mechanisms underlying tumor-immune interactions.

Publications:

1. Wang, X,*, Wang, K.*, Zhang, W.*, Tang, Z., Zhang, H., Cheng, Y., Zhou, D., Zhang, C., Zhong, W.-Z., Ma, Q.# , Xu, J.# , Hu, Z.# (2025). Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells. Genome Biology.

2. Ekstrom, T. L., Rosok, R. M., Abdelrahman, A. M., Parassiadis, C., Manjunath, M., Dittrich, M. Y., Wang, X., Kutschat, A. P., Kanakan, A., Rajput, A., Schacherer, N., Lukic, T., Carlson, D. M., Thiel, J., Kopp, W., Stroebel, P., Ellenrieder, V., Gaedcke, J., Dong, M., Najafova, Z., … Johnsen, S. A. (2025). Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer. Gut.

3. Wang, X.*, Kutschat, A. P.*, Aggrey-Fynn, J., Hamdan, F. H., Graham, R. P., Wixom, A. Q., Souto, Y., LadiganBadura, S., Yonkus, J. A., Abdelrahman, A. M., Alva-Ruiz, R., Gaedcke, J., Ströbel, P., Kosinsky, R. L., Wegwitz, F., Hermann, P., Truty, M. J., Siveke, J. T., Hahn, S. A., Hessmann, E., … Najafova, Z. (2023). Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma. Molecular Cancer Research.

4. Guo, W.*, Wang, X.*, Lu, B., Yu, J., Xu, M., Huang, R., Cheng, M., Yang, M., Zhao, W. # , & Zou, C.# (2023). Super enhancer-driven MLX mediates redox balance maintenance via SLC7A11 in osteosarcoma. Cell Death & Disease.

5. Wang, K., Hou, L., Wang, X., Zhai, X., Lu, Z., Zi, Z., Zhai, W., He, X., Curtis, C., Zhou, D. # , & Hu, Z. # (2023). PhyloVelo enhances transcriptomic velocity field mapping using monotonically expressed genes. Nature Biotechnology.

6. Zhang, Z., Wang, X., Hamdan, F. H., Likhobabina, A., Patil, S., Aperdannier, L., Sen, M., Traub, J., Neesse, A., Fischer, A., Papantonis, A., Singh, S. K., Ellenrieder, V., Johnsen, S. A., & Hessmann, E. (2023). NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming. Cellular and Molecular Gastroenterology and Hepatology.

7. Hamdan, F. H., Abdelrahman, A. M.*, Kutschat, A. P.*, Wang, X.*, Ekstrom, T. L., Jalan-Sakrikar, N., Wegner Wippel, C., Taheri, N., Tamon, L., Kopp, W., Aggrey-Fynn, J., Bhagwate, A. V., Alva-Ruiz, R., Lynch, I., Yonkus, J., Kosinsky, R. L., Gaedcke, J., Hahn, S. A., Siveke, J. T., Graham, R., … Johnsen, S. A# . (2023). Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer. Gut.

8. Wang, X., Kutschat, A., Yamada, M., Prokakis, E., Boettcher, P., Tanaka, K., Doki, Y., Hamdan, F., and Johnsen, S# . (2021). Bromodomain protein BRDT directs ΔNp63 function and super enhancer activity in a subset of esophageal squamous cell carcinomas. Cell Death & Differentiation.

9. Kutschat, A.*, Hamdan, F.*, Wang, X., Wixom, A., Najafova, Z., Gibhardt, C., Kopp, W., Gaedcke, J., Stroebel, P., Ellenrieder, V., Bogeski, I., Hessmann, E. and Johnsen, S. A. (2021). Calcium-dependent epigenetic reprogramming in pancreatic cancer. Cancer Research.

10. Patil, S., Steuber, B., Kopp, W., Kari, V., Urbach, L., Wang, X., Küffer, S., Bohnenberger, H., Spyropoulou, D., Zhang, Z., Versemann, L., Bösherz, M., Brunner, M., Gaedcke, J., Ströbel, P., Zhang, J., Neesse, A., Ellenrieder, V., Singh, S., Johnsen, S. A. and Hessmann, E. (2020). EZH2 regulates pancreatic cancer subtype identity and tumor progression via transcriptional repression of GATA6. Cancer Research.

11. Kosinsky, R.L., Zerche, M., Saul, D., Wang, X., Wohn, L., Wegwitz, F., Begus-Nahrmann, Y. and Johnsen, S. A.(2020). USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity. Cell Death & Differentiation.

12. Sen, M., Wang, X., Hamdan, F.H., Rapp, J., Eggert, J., Kosinsky, R.L., Wegwitz, F., Kutschat, A.P., Younesi, F.S.,Gaedcke, J., Grade, M., Hessmann, E., Papantonis, A., Ströbel, P. and Johnsen, S. A. (2019). ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells. Clinical Epigenetics.

13. Wang, X. *, Gao, D. *, Sun, J., Liu, M., Lun, Y., Zheng, J., Wang, S., Cui, Q., Wang, X# . and Huang, S# . (2016). An exon skipping in a SEPALLATA‐Like gene is associated with perturbed floral and fruits development in cucumber. Journal of Integrative Plant Biology.

14. Lun, Y.*, Wang, X.*, Zhang, C., Yang, L., Gao, D., Chen, H. and Huang, S. (2016). A CsYcf54 variant conferring light green coloration in cucumber. Euphytica.

15. Wang, Q., Wang, S., Gan, S., Wang, X., Liu, J. and Wang, X. (2016). Role of specific phosphorylation sites of Arabidopsis brassinosteroid-insensitive 1 receptor kinase in plant growth and development. Journal of Plant Growth Regulation.