Lab Member

Yan Zhang, Ph.D.

张妍

Position:

Postdoctoral Fellow (2025)

Email:

megara_816@hotmail.com

Education:

2018.08 - 2022.12 澳大利亚莫那什大学 免疫学 博士

研究方向：B 细胞分化的表观遗传学调控

2015.09 - 2018.07 重庆医科大学 肿瘤学 学术型医学硕士

研究方向：肿瘤抑癌因子的表观遗传学调控

2009.09 - 2014.07 西安交通大学 临床医学 医学学士

Work Experiences:

2024.09 - 至今 重庆医科大学附属第二医院 规培医生；

2023.09 - 2024.08 重庆大学附属肿瘤医院 博士后；

2022.08 - 2023.03 澳大利亚莫纳什大学研究员；

Publication:

  1. 2025 Y. Zhang, C. Chakma , A. Kirn , A. Zaini, R. Farighi, L. Xie , D. López-Ureña , S. J. Mileto , D. Lyras , C. Zaph , J. R Groom , K.L. Good-Jacobson. MLL1 directs gut-associated antibody responses to helminth and bacterial infections [Revising for Cell reports]

  2. 2023 A. Zaini, L. Dalit, A. A. Sheikh, Y. Zhang, D. Thiele, J. Runting, G. Rodrigues, J. Ng, M.Bramhall, S. Scheer, L. Hailes, J.R. Groom, K.L. Good-Jacobson * and C. Zaph*. Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response. Mucosal Immunol. 2023 Jul 15:S1933-0219(23)00052-1. [IF: 9.02]

  3. 2019 Y. Zhang, K.L. Good-Jacobson Epigenetic regulation of B cell fate and function during an immune response, Immunol Rev, 288(2019) 75-84. [IF: 10.983]

  4. 2019 Y. Zhang, H. Xu, J. Mu, S. Guo, L. Ye, D. Li, W. Peng, X. He, T. Xiang. Inactivation of ADAMTS18 by aberrant promoter hypermethylation contribute to lung cancer progression, Journal of cellular physiology, 234 (2019) 6965-6975. [IF: 6.513]

  5. 2019 Q. Xiang, D. Zhou, X. He, J. Fan, J. Tang, Z. Qiu, Y. Zhang, J. Qiu, Y. Xu, G. Lai. The zinc finger protein GATA4 induces mesenchymal-to-epithelial transition and cellular senescence through the nuclear factor-kappaB pathway in hepatocellular carcinoma, Journal of gastroenterology and hepatology, 34 (2019) 2196-2205. [IF: 4.029]

  6. 2018 Y. Zhang, J. Fan, Y. Fan, L. Li, X. He, Q. Xiang, J. Mu, D. Zhou, X. Sun, Y. Yang, G. Ren, Q. Tao, T. Xiang. The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via beta-catenin/Cdc25c signaling and G2/M arrest, Clin Epigenetics, 10 (2018) 26. [IF: 7.28]

  7. 2018 J. Fan, Y. Zhang, J. Mu, X. He, B. Shao, D. Zhou, W. Peng, J. Tang, Y. Jiang, G. Ren, T.Xiang. TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/beta-catenin signaling pathway in nasopharyngeal carcinoma cells, Clin Epigenetics, 10 (2018) 103.[IF: 7.28]